Preliminary Investigations of a Diuretic Screening Method Converted from HPLC/MS/MS to UPLC/MS/MS

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Russell Watts, Michelle Wood (Waters);Philip Grace, Simon Hudson (HFL, Fordham, Cambridgeshire, UK
TIAFT, Aug. 26-30, Slovenia
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The World Anti-Doping Agency (WADA) states all laboratories must be able to confidently detect the minimal required performance limit (MRPL) of 250 ng/mL. The increased number of athlete samples being tested each year has led to a need for a high throughput rapid screen for prohibited substances. Here we describe a rapid and sensitive UPLC/MS/MS method for the screening of diuretic compounds. The conversion of a qualitative diuretic screening method used in sports doping analysis from HPLC/MS/MS (total run time of 10 min.) to UPLC/MS/MS, where the analysis time is reduced without any loss of sensitivity and selectivity. This poster was presented at The International Association of Forensic Toxicologists (TIAFT), Aug. 26-30, 2006 in Ljubljiana, Slovenia.

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