A Comparison of HPLC and UPLC for Metabolite Screening in Drug Discovery Using TOF-MS

Library Number:
720001934EN
Part Number:
720001934EN
Author(s):
Robert Plumb, Jose Castro-Perez, Kate Yu, John Shockor
Source:
LC/MS Montreux Symposium 2006 November 8 - 10 Montreux, Switzerland
Content Type:
Posters
Content Subtype:
Montreux
Related Products:
Ultra Performance Liquid Chromatography system (UPLC) and HPLC are compared to show the difference between the two technologies when coupled with a TOF-MS and triple quadrupole mass spectrometer for metabolism studies. In order to show the potential of this particular approach, a number of analytical runs will be shown, where different in vitro incubations are compared for Buspirone and Midazolam.

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