16-O/18-O Labeling Quantitative Analysis of Tryptically Digested Mouse Serum Using LC Coupled with MALDI MS and MS/MS

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Marten Snel, Richard Tyldesley-Worster, P. Davidson, James Langridge, Iain Campuzano, Thérèse McKenna (Waters);Greg Cavey, D. Monsma, Craig Webb (Van Andel Research Institute)
ASMS 2006 May 28-June 1 Seattle, Wa; IMSC 2006, Aug. 27-Sept. 1, 2006, Prague
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A method based on 2D-LC and LC-MALDI MS/MS for analyzing isotopically labelled serum digests has beendeveloped.A high repetition rate laser system has been implemented to increase throughput. Some proteins have been identified occurring only in the control sample. Comparison of the matching peptides, between the control and tumour samples, has been achieved and identified protein expression changes.

This poster was presented at ASMS 2006 and at IMSC 2006.

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