The Combination of Ion Mobility with Orthogonal TOF Mass Spectrometry to Improve the Limits of Detection for MALDI Analysis
ASMS 2006, Instrumentation TOF-MS: Novel experimental
instrumentation incorporating IMS and TOF MS. IMS allows different
charge state MALDI ions to be isolated.The use of ion mobility in this
instrument allows the duty cycle of the orthogonal-TOF to be increased
across the whole m/z range.The extra sensitivity gained from the
increase in duty cycle allows confident protein identifications to be
made from sample concentrations as low as 125 attomol.