A Novel Adaptive Background Subtraction Algorithm for Reduction of Chemical Noise in Mass Spectra.

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Martin R Green, Keith Richardson,Martin Palmer, Richard Denny, Iain Campuzano (Waters);John Skilling (Maximum Entropy Data Consultants Ltd)
ASMS 2006 May 28-June 1 Seattle, Wa
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ASMS 2006, Computer Applications: The Adaptive Background Subtraction (ABS) algorithm is capable of dramatically reducing background with short range (~ 1Da) periodicity and longer range intensity variation. The algorithm adapts to the nature of thebackground throughout the mass spectrum resulting in optimum signal to noise throughout the acquired mass range. For very complex protein digest samples application of ABS consistently improves peptide coverage and protein identification confidence from protein databank searches.

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