Exploring Impurity Profiling Techniques: UPLC Coupled with oa-ToF Mass Spectroscopy for Method Development and Structural Characterization of Impurities in a Pharmaceutical Drug Substance

Library Number:
720001570EN
Part Number:
720001570EN
Author(s):
Michael D. Jones, Chris L. Stumpf, Paul D. Rainville, Paul M. Lefebvre, Andrew J. Aubin, Robert S. Plumb (Waters)
Source:
Pittcon 2006
Content Type:
Posters
Content Subtype:
Pittcon
Related Products:
 

The extra resolution and throughput of UPLC makes it the ideal liquid chromatography tool for impurity and degradation analysis. Applying oa-TOf MS with UPLC techniques to assist with achieving exact mass alllow for the confirmation of known or hypothesized degradant/impurity substances. UPLC oa-Tof helps fast tracking method development of purity analysis methods.

 


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