Quantification of Diagnostic Protein Signatures of Polygenic Diseases Characterized by Mass Spectrometric Proteome Analysis: A Study on Mamma Carcinoma
Tissue samples from three individuals that belong to the group
of post-menopausal women suffering from invasive ductal carcinoma were
studied. The biological material has been extracted after full mammary
gland removal. In this study, a comprehensive MS-based discovery
strategy is applied for a polygenic disease. This method employs the
separation and detection of non-labelled tryptic fragments by means of
an LC-MS acquisition.