Exploiting Accurate Mass Information for Metabolite Structure Elucidation Using a Data Independent Strategy.

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Jing Lin, Stephanie Dudd, Jose Castro-Perez, John Shockcor, Kate Yu
Pharmaceutical Sciences World Congress, April 22 - 25, Amsterdam, The Netherlands
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Other Symposium
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Finding and identifying metabolites in cold in vivo studies by LC-MS is extremely challenging, as metabolites are often present at such low levels that chromatographically they are indistinguishable from the background endogenous materials.  In practice this means several LC-MS-(MS) experiments are usually performed for each sample to fully explain the metabolic fate of the compound. In this work we describe a novel approach that enables all of the key metabolite information to be collected in a single LC/MS run.

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