Indirect Comparison of the MassTrak Reagent Kit for LC/MS/MS Analysis of Whole Blood Tacrolimus with Three Established Immunoassays

Library Number:
720002304EN
Part Number:
720002304EN
Author(s):
Donald P. Cooper, Kimberly L. Napoli, Catherine Hammett-Stabler, and Michael R. Morris
Source:
AACC 2007, July 15 - 19, San Diego, Ca
Content Type:
Posters
Content Subtype:
AACC
Compounds:
Tacrolimus
Matrix:
Whole blood
In routine clinical laboratories it is not practical to maintain multiple assays for the same analyte for logistic and financial reasons, making it difficult to perform long-term method comparison studies when new analytical tests are introduced. We have used external quality assurance (EQA) returns as an indirect means to compare the MassTrak™ LC/MS/MS whole blood tacrolimus assay with established immunoassays. For some of the assays, there are a large number of test centres contributing data so that the method mean provides a  reliable measure of the accuracy of that technique. Furthermore, the same sample set may be used for all the comparisons and long-term comparative assay performance inferences can be made.

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