High Sensitivity Peptide Analysis Using a Novel MALDI Substrate
A patterned self-assembled monolayer (SAM) that confers zones
of differing wettability was constructed on a goldcoated silicon wafer
to serve as a sample platform for MALDI TOF analysis. The usage of this
substrate greatly increased the sensitivity of peptide analysis,
resulting in 10 to 100-fold improvements compared to traditional MALDI
TOF MS on a stainless steel plate.