Open-access UPLC/MS Solutions for Analytical Support Laboratories

Library Number:
720002323EN
Part Number:
720002323EN
Author(s):
Marian Twohig, Paul Lefebvre, Darcy Shave, Rob Plumb
Source:
Drug Discovery 2007, August 6 - 9, Boston, MA
Content Type:
Posters
Content Subtype:
Other Symposium
Related Products:
 
Open-access mass spectrometry has been successfully implemented by analytical chemistry support laboratories as an effective way of rapidly characterizing synthetic compounds and answering complex structural questions. These questions include issues such as correct formula (nominal mass), reaction completion (OA LC/MS), purity (UV and ELSD), and structural elucidation (HR-MS in conjunction with NMR). Single quadrupole mass spectrometers are used routinely to answer less complex questions relating to nominal mass confirmation. Occasionally nominal mass is not sufficient to provide answers relating to less well characterized reactions. High resolution mass spectrometers can identify unexpected byproducts and complete unknowns. 

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