Solid-Phase Extraction Method Development Strategies for the Determination of Drugs in Biological Matrices

Library Number:
980282
Author(s):
Y-F. Cheng;P. Iraneta, L. Bean;E.S.P. Bouvier, U.D. Neue, D.J. Phillips, M. Capparella and J. Carmody
Source:
Paper presented at Pittcon ''98, New Orleans, March 1-5, 1998
Content Type:
Orals/Lectures
Content Subtype:
Pittcon
Compounds:
Antidepressants; Sulfamerazine; Ibuprofen; Naproxen; Salicylic acid; Minocycline; Tetracycline; Demeclocycline; Verapamil; Methoxyverapamil; Norverapamil; Betamethasone; Acetaminophen; Ranitidine; Procainamide; Theophylline; Theobromine; Caffeine; Oxycodone; Naltrexone; Salbutamol; Paraxanthine; Sulfadiazine; Propranolol; Dipropyl phthalate; Betamethasone valerate; Enalapril; Enalaprilat
Matrix:
human plasma, porcine serum
Column:
SymmetryShield RP8
Dimensions:
3.9 x 150 mm
--Using the one-dimensional SPE method, we were able to obtain very high recoveries (all greater than 86%) and excellent reproducibility (all less than 5.0%) for a wide range of drugs. These compounds included acids, neutrals, and bases.

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