Demonstrating an ease-of-use benchtop Time of Flight Detector as an ease of use solution for routine accurate mass measurements in forced degradation studies

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Chris Henry, Paul Rainville
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Degradation of glipizide was successfully characterized using the ToF analyser coupled to the UHPLC system. The software was able to identify glipizide and its degradants with a high degree of confidence automatically, by intelligent interrogation of the data. The acquisition of high energy data, generating fragment ions, provided rigor to compound ID. All compounds and fragment ions presented exhibited mass accuracy of less than 5ppm.The intelligent software, combined with the accurate mass analyser’s automatic set-up, provides access to accurate mass measurement data in a routine workflow.


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