Determination of Fatty Acids Composition in Polysorbate 20 Pharmaceutical Raw Material Using HPLC with MS Detection

Library Number:
APNT135087356
Part Number:
720007336EN
Author(s):
Margaret Maziarz, Paul D. Rainville
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
Pharmaceutical
 
 
 

The developed HPLC-MS method allows fast determination of fatty acids composition in polysorbate 20 and eliminates the need for a complex hydrolysis and derivatization procedure of the test samples. The mass spectral data enables accurate and quick identification of analytes by mass detection. The new method offers accurate quality and purity assessment of polysorbate 20 pharmaceutical raw material, while improving the confidence associated with sample component confirmation.


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