The use of single quadrupole mass detectors such as the ACQUITY QDa, offers several advantages over optical detectors, such as UV-Vis. The advantages include increased selectivity, lower detection limits, and the ability to collect mass spectral information on components of a sample. In this application note, we highlight a method for the separation of fourteen organic acids using the ACQUITY Premier CSH Phenyl-Hexyl Column. The analysis was carried out on an ACQUITY UPLC H-Class PLUS coupled with an ACQUITY QDa Mass Detector. The use of the ACQUITY QDa Mass Detector improves the selectivity of the method, resulting in less impact on the analysis from sample matrix co-elutions, allowing for easier integration of the target organic acids and more accurate analysis.