Improving UPLC-FLR-MS N-glycan Analysis of Disulfide-rich Fusion Proteins Through Optimization of Sample Preparation

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Ximo Zhang, Mauro Sassi, Erika Birolo, Nunzio Sepe, Paolo Felici, Angelo Palmese, Robert E. Birdsall, Ying Qing Yu
Waters, Merck
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Application Notes
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Application Notes
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Here, we report a new sample preparation method to improve the UPLC-FLR-MS-based N-glycan analysis of fusion proteins exhibiting a high level of disulfide bonds and complex glycoprofiles using a modified protocol for the Waters GlycoWorks RapiFluor-MS N-glycan Kit.

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