Improving UPLC-FLR-MS N-glycan Analysis of Disulfide-rich Fusion Proteins Through Optimization of Sample Preparation

Library Number:
APNT135082030
Part Number:
720007162EN
Author(s):
Ximo Zhang, Mauro Sassi, Erika Birolo, Nunzio Sepe, Paolo Felici, Angelo Palmese, Robert E. Birdsall, Ying Qing Yu
Source:
Waters, Merck
Content Type:
Application Notes
Content Subtype:
Application Notes
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Here, we report a new sample preparation method to improve the UPLC-FLR-MS-based N-glycan analysis of fusion proteins exhibiting a high level of disulfide bonds and complex glycoprofiles using a modified protocol for the Waters GlycoWorks RapiFluor-MS N-glycan Kit.


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