Accurate LC-MS Bioanalytical Quantification of Itaconic Acid Using the Automated Andrew+ Pipetting Robot for Ostro Sample Preparation

Library Number:
APNT135081775
Part Number:
720007176EN
Author(s):
Kathryn Brennan, Mary Trudeau
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
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This application note demonstrates the capabilities of the Andrew+ Pipetting Robot, an automated liquid handling device, for sample preparation and extraction. The Andrew+ was used to autonomously prepare and extract itaconic acid from human plasma using the Ostro Protein Precipitation and Phospholipid Removal 96-well Plate, with subsequent LC-MS/MS analysis and quantification using the ACQUITY PREMIER System and Xevo TQ-S micro Mass Spectrometer.


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