Demonstration of LC-MS Nitrosamine Impurity Quantification Performance using Automated Sample Preparation with the Andrew+ Pipetting Robot

Library Number:
APNT135080267
Part Number:
720007134EN
Author(s):
Mary Trudeau, Nigel Skinner
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
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This automated method created with OneLab, and performed on the Andrew+ Pipetting Robot, developed herein, was able to perform simple serial dilution to generate calibration curves for analysis of nitrosamine impurities with no manual intervention by the analyst. This broadly applicable method can be use independently, or as part of a more complex sample workflow for robust LC-MS quantification analysis. In addition, OneLab methods are traceable and easily transferable, ensuring method reproducibility performance: day-to-day, user-to-user, system-to-system, and lab-to-lab.


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