ACQUITY PREMIER LC Technology Significantly Improves Sensitivity, Peak Shape, and Recovery for Phosphorylated and Carboxylate Lipids

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Giorgis Isaac, Robert S. Plumb
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Phosphorylated and carboxylate lipid species are metal sensitive and can readily adsorb to stainless steel surfaces within the flow path of UPLC systems. This process can lead to poor peak shape, low recovery and reduction in sensitivity. Here we show that the ACQUITY PREMIER CSH C18 Column with ACQUITY PREMIER System can significantly improve sensitivity, peak shape, and recovery of phosphorylated and carboxylate lipids compared to ACQUITY standard column and stainless steel ACQUITY UPLC I-Class System.

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