Peptide Mapping using Binary Biocompatible LC Systems: Evaluation of Retention Time Precision and Mixing Effects on Waters and Competitive LCs

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Jennifer Simeone, Paula Hong
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Application Notes
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Application Notes
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This application note demonstrates a high level of reproducibility, which is a critical attribute of reliable and accurate data. In addition, a mixer designed specifically for use with trifluoroacetic acid containing mobile phases shows a significant reduction in baseline noise, improving signal to noise for increased assay sensitivity. In addition to the ACQUITY UPLC H-Class PLUS Bio Binary System, two other competitive LC systems-both equipped with binary high-pressure mixing pumps-were evaluated for impact on retention time reproducibility and baseline noise.

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