Intact Mass Confirmation Analysis on the BioAccord LC-MS System for a Variety of Extensively Modified Oligonucleotides

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Catalin E. Doneanu, Jonathan Fox, Emma Harry, Chris Knowles, Ying Qing Yu, Joseph
Waters Corporation
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Application Notes
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Application Notes
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  • An automated intact mass workflow inside the waters_connect informatics software is shown to provide good mass accuracy (less than 15 ppm) for intact mass confirmation of oligonucleotides bearing seven different chemical modifications
  • The Bayes Spray algorithm embedded in waters_connect provides accurate results for deconvolution of heavily modified oligonucleotides

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