Chromatographic columns, if maintained properly, can be used for hundreds to thousands of injections. However, no matter how well maintained, a column will eventually lose performance. A column with poor performance can produce failing results and lead to costly rework. In order to track column lifetime, routine injections of a performance standard can be used. In this work, a Quality Control Reference Material (QCRM) is used to monitor column performance throughout testing of protein precipitated plasma.