Ensuring Data Quality and Column Performance in Bioanalytical Workflows Using Routine Injections of QC Reference Materials

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Kenneth D. Berthelette, Thomas Walter, Paula Orens, Kim Haynes
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Application Notes
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Technical Notes
Related Products:
Quad LCMS QC Reference Material

Chromatographic columns, if maintained properly, can be used for hundreds to thousands of injections. However, no matter how well maintained, a column will eventually lose performance. A column with poor performance can produce failing results and lead to costly rework. In order to track column lifetime, routine injections of a performance standard can be used. In this work, a Quality Control Reference Material (QCRM) is used to monitor column performance throughout testing of protein precipitated plasma.

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