Improved Chromatographic Performance with a PREMIER Peptide C18 Column Versus a Titanium-Lined C18 Column Technology

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Maureen DeLoffi, Jennifer M. Nguyen, Gary Izzo, Matthew A. Lauber, Mike Savaria
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Application Notes
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Technical Notes
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In this application brief, we highlight the performance advantage of the ACQUITY PREMIER Peptide C18 Columns in achieving high-quality separations for phosphopeptides and some putative sequence variants that cannot be seen with the titanium lined C18 column. For these phosphopeptides, the ACQUITY PREMIER Peptide C18 Column provides improved recovery, better peak shape, and a significant reduction in the need for sample conditioning. In addition, the PREMIER column demonstrates greater packed bed stability at high pressures, making it ideal for high throughput applications.

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