Improved Chromatographic Performance with a PREMIER Peptide C18 Column Versus a Titanium-Lined C18 Column Technology

Library Number:
APNT135075359
Part Number:
720007022EN
Author(s):
Maureen DeLoffi, Jennifer M. Nguyen, Gary Izzo, Matthew A. Lauber, Mike Savaria
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
 
 
 
 
 
 

In this application brief, we highlight the performance advantage of the ACQUITY PREMIER Peptide C18 Columns in achieving high-quality separations for phosphopeptides and some putative sequence variants that cannot be seen with the titanium lined C18 column. For these phosphopeptides, the ACQUITY PREMIER Peptide C18 Column provides improved recovery, better peak shape, and a significant reduction in the need for sample conditioning. In addition, the PREMIER column demonstrates greater packed bed stability at high pressures, making it ideal for high throughput applications.


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