Comprehending COVID-19: Fast Analysis of Ribavirin and Related Compounds Using Hydrophilic Interaction Chromatography

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Kenneth D. Berthelette Thomas Walter Sherri Naughton Jonathan E. Turner Nick Zampa
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A rapid method for the separation of ribavirin and related compounds was demonstrated using HILIC with an ACQUITY UPLC BEH Amide Column. Excellent resolution of ribavirin and uridine was achieved, which is critical for the quantitation of ribavirin using LC-MS because uridine is isobaric. This method may be useful for a range of applications, including purity determination of ribavirin and therapeutic drug monitoring. The COVID-19 pandemic further motivates the need for advances in ribavirin analysis, however, improvements in chromatographic methods for ribavirin analysis remains useful regardless of the clinical outcome for ribavirin as a treatment COVID-19.

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