Comprehending COVID-19: Preliminary Examination of the SARS-CoV-2 Spike Protein by Peptide Mapping

Library Number:
APNT135071693
Part Number:
720006909EN
Author(s):
Wenjing Li, Matthew A. Lauber
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes

The SARS-CoV-2 spike protein has rightly garnered attention as a leading candidate for protein-based vaccines for COVID-19. Multiple studies have shown that neutralizing antibodies, from convalescent coronavirus patients, bind to the spike protein at both peptide and peptidoglycan epitopes. Peptide mapping analyses by liquid chromatography and mass spectrometry might therefore prove to be very useful during the development and QC analysis of new protein-based vaccine candidates for the novel coronavirus.


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