The Analysis of Tetracycline and Sulfonamide Antibiotics in Shrimp Tissue using Liquid Chromatography Tandem Quadrupole Mass Spectrometry

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Christelle Robert, Marijn Van Hulle, Simon Hird, Luc Demoulin, Gilles Pierret, Nathalie Gillard
CER Groupe, Waters
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The method described here proved to be a sensitive and robust multiresidue method for the determination of a series of different antibiotics, namelytetracyclines, sulfonamides, trimethoprim, ormetoprim, and dapsone antibiotics, using an ACQUITY UPLC I-Class PLUS System coupled to a Xevo TQ-S micro MS/MS system. The method allows for a fast and reliable quantitation down to concentrations well below typical MRLs and was successfully validated according the European Commission Decision 2002/657, presenting satisfactory results for tetracyclines, sulphonamides, and related antibiotics in shrimp tissue. The procedure can also be applied to other animal and fish tissues after suitable validation. This cost-effective method can be easily implemented in routine testing laboratories, has been demonstrated as suitable for checking compliance with MRLs, and has the potential for screening at much lower concentrations, such as for food business operators’ due diligence testing.

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