This application note shows the performance method for determination of acrylamide in processed foods by UPLC-MS/MS on an ACQUITY UPLC I-Class PLUS System coupled to the Xevo TQ-S cronos. Calibration characteristics, linearity, and sensitivity were all shown to be suitable for monitoring mitigation measures and checking compliance with EU benchmark levels for acrylamide in potato chips.
The robustness study was performed under the most extreme source parameters* to challenge the instrument under heavy matrix load. The results of the robustness study show the Xevo TQ-S cronos to be reliable for routine operation, without operator intervention during extended periods of analysis even for challenging small, polar analytes in complex food matrices. This superior performance can be attributed to the technology features of the Xevo TQ-S cronos, including the reverse cone design (shielding the inner cone from contamination), orthogonal geometry ion source, StepWave ion guide, and the T-Wave enabled collision cell.