Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System

Library Number:
APNT135037348
Part Number:
720006672EN
Author(s):
Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 

This application note dmeontstrates a direct IEX-MS method with broad utility for the successful detection of mAb charge variants. Platform methods can be easily developed using the BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord LC-MS System which provide robust and reproducible separations along with high quality mass spectra in the elucidation of various mAb-charge variant species.


Title Format File Size
Download PDF PDF 811.03kB