Compliant Monitoring of Monoclonal Antibody Titer and Primary Structure Attributes Using a 2D-LC/MS System with UNIFI Informatics

Library Number:
APNT135036914
Part Number:
720006691EN
Author(s):
Brooke M. Koshel, Robert E. Birdsall, and Ying Qing Yu
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
 

 

In this work, 2D-LC/MS was used to assess monoclonal antibody (mAb) titer and confirm both product mass and glycosylation profile. The simplicity of data collection on a single platform configured for 1D titer measurements and 2D product profiling with MS detection is demonstrated.

 


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