Simultaneous Analysis of Vitamins A and E in Serum by UPLC-MS/MS for Clinical Research

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Michelle Wills, Gareth Hammond, and Lisa Calton
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A fast-clinical research method has been developed for the simultaneous analysis of vitamins A and E in serum. Using only 100 μL of serum in combination with a short run time, this method allows for high throughput of samples. In addition, the use of Oasis PRiME HLB μElution Plates minimizes phospholipid interferences. The assay described demonstrates excellent precision over five days and linearity across the required range with no significant carryover and no endogenous or exogenous interferences observed. The method demonstrates good agreement with UK NEQAS samples.

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