Vion IMS QTof Shows Three Orders of Magnitude Linearity of Response for Metabolic Profiling

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Adam King and Chris Hughes
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Application Notes
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Technical Notes
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This technology brief demonstrates the linear dynamic range of the Vion IMS QTof Mass Spectrometer for metabolomics analysis.

Metabolic profiling provides a unique insight into biochemical changes as a result of disease or toxicity. The biological variation that can be seen when comparing diseased subjects to those of healthy controls produces a broad response from metabolites often to the extremes of instrument capabilities. The UPLC-MS-MS system showed a linear dynamic range over three orders of magnitude for small molecules in urine, making the system ideal for the semi-quantitative measurement and identification of metabolites in biological fluids.


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