Forced Degradation of Cannabidiol

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Catharine Layton, Jacquelyn Runco, and Andrew Aubin
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Forced Degradation

The Use of Orthogonal Methods to Monitor the Major Degradation Products of Cannabidiol (CBD).

Through a preliminary forced degradation study of crystalline CBD, we demonstrate how UPLC and UPC2 can be applied collectively to monitor solution stability. The ACQUITY UPLC H-Class instrument uses conventional reversed-phase chromatography, while the ACQUITY UPC2 system provides a stereo-chemical separation of important structural isomers via convergence chromatography. When these techniques are coupled with photo diode array (PDA) and mass spectrometry (MS), the chemical and structural identity of important CBD degradation products is determined.

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