Ion Mobility Separation Coupled With Desorption Electrospray Ionization Mass Spectrometry for High Specificity MS Imaging

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Emmanuelle Claude
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Here we demonstrate that DESI imaging can be coupled with ion mobility separation (IMS), providing separation of ions in the gas phase based on their size, shape and charge. This capability provides evidence that DESI ionizes multiple classes of lipids directly from the surface of a mouse brain tissue section and the lipid ions are present in different charge states.

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