Dilute and Shoot Method for the Determination of Tobacco-Specific Nitrosamines (TSNAs) in Smokeless Tobacco Products by UPLC-MS/MS

Library Number:
APNT134876982
Part Number:
720005595en
Author(s):
Naren Meruva, Dimple Shah, Xiaojie Tan, and Jennifer Burgess
Source:
Waters Corporation
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
 

In this application note, we describe a UPLC-MS/MS method for TSNA analysis in tobacco products that has been developed based on the CORESTA standard (CRM-72), and provides further improvements in sensitivity, linear dynamic range, sample workflow, and overall analysis throughput.

This method is applicable to the determination of TSNAs in tobacco and smokeless tobacco products including snus, moist snuff, dry snuff, and chewing tobacco.


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