Rapid Analysis of Cocaine and Metabolites by Mixed-Mode μElution SPE Combined with UPLC-MS/MS

Library Number:
APNT134876342
Part Number:
720005571EN
Author(s):
Cheryl Boissel, Bonnie Alden, Jonathan Danaceau, and Erin Chambers
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
 
 
 
 

This application note details the extraction of cocaine, benzoylecgonine and cocaethylene from urine samples using Oasis MCX μElution Mixed-mode Cation Exchange Plates for forensic toxicology.

The water wettability of this sorbent enabled the elimination of conditioning and equilibration steps, simplifying the extraction procedure and speeding up the sample preparation workflow, without sacrificing performance. In addition, the low elution volume eliminated the need for evaporation and reconstitution of the final eluate.


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