Rapid Analysis of Cocaine and Metabolites by Mixed-Mode μElution SPE Combined with UPLC-MS/MS

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Cheryl Boissel, Bonnie Alden, Jonathan Danaceau, and Erin Chambers
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Application Notes
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This application note details the extraction of cocaine, benzoylecgonine and cocaethylene from urine samples using Oasis MCX μElution Mixed-mode Cation Exchange Plates for forensic toxicology.

The water wettability of this sorbent enabled the elimination of conditioning and equilibration steps, simplifying the extraction procedure and speeding up the sample preparation workflow, without sacrificing performance. In addition, the low elution volume eliminated the need for evaporation and reconstitution of the final eluate.

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