Routine LC-MS Analysis of Intact Antibodies

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Henry Shion
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Application Notes
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Application Notes
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Xevo G2-S QTof

This application note describes in detail the routine LC-MS analysis of intact antibodies using the Waters® mAb Mass Check Standard.

LC-MS intact mass analysis of antibodies becomes a routine and high throughput analysis in light of the advancements made in LC-MS technologies and informatics. Using the provided LC-MS experimental conditions as well as data processing settings, high quality intact mAb data can be obtained routinely for mAb identification and relative glycoform quantitation.

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