Demonstration of Collision Cross Section (CCS) Value Conservation Across LC and GC Analyses

Library Number:
APNT134874539
Part Number:
720005592en
Author(s):
Lauren Mullin, Gareth Cleland, and Mike McCullagh
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
 
 
 

Contaminant identification in food and environmental matrices using both GC and LC-MS techniques are widely implemented, although challenges with matrix effects, false detections, and reproducibility of ion ratios exist.

CCS values are robust and precise values associated with physical properties of an ion, and are conserved regardless of chromatographic technique implemented.

In this technology brief we demonstrate the application of travelling wave ion mobility spectrometry (TW-IMS) coupled to a quadrupole time-of-flight (QTof) MS to generate a robust and unique additional identification point for contaminant analysis.


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