Improving the Detection of Thyroglobulin in Human Plasma for Clinical Research by Combining SISCAPA Enrichment and Microflow LC-MS

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Jay S. Johnson, Morteza Razavi, James Murphy, Selena Larkin, Paul Rainville
Waters, SISCAPA Assay Technologies
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Application Notes
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Application Notes
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This application note investigates if the ionKey/MS System operating in a dual-pump trapping configuration can provide reductions in LLOQ levels for Thyroglobulin (Tg).

The above procedure does provide acceptable LLOQ levels for Tg using significantly less plasma while maintaining the requisite accuracy, better precision, and throughput levels exemplified by standard flow LC-MS methods. Accordingly, microflow is a viable and attractive solution for clinical research.

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