Influence of Sample Injection Parameters on the Performance of UltraPerformance Convergence Chromatography (UPC2) Coupled with MS Detection

Library Number:
Part Number:
Christopher Knappy, Norman W Smith, Arundhuti Sen, Paul D Rainville, Robert S Plumb
Waters, King’s College
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:

This study presented the influence of sample injection volume and composition on both the response produced from a MS detector, and on the peak capacity produced by the chromatographic separation. Higher concentrations of water in the sample solvent and higher injection volumes resulted in lower chromatographic peak capacities produced by the separation, while producing higher MS response. Therefore, depending on the type of analysis being carried out, i.e., qualitative or quantitative, one must balance the sample injection parameters to obtain the aim of the analysis.

Title Format File Size
Download (720005446en) PDF 820.72kB