HPLC Method Transfer for Analysis of Metoclopramide HCl and Related Substances from an Agilent 1100 Series LC System to an ACQUITY Arc System

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Margaret Maziarz and Mark Wrona
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Application Notes
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Technical Notes
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The goal of this technology brief is to  transfer an HPLC method for related substances of metoclopramide HCl from an Agilent 1100 Series LC System to an ACQUITY® Arc™ System, replicating the chromatographic separation and meeting system suitability specifications.

The HPLC method for metoclopramide and its related substances was successfully transferred from an Agilent 1100 Series LC System to an ACQUITY Arc System. The ACQUITY Arc System successfully replicated the quality of chromatographic separation obtained on the Agilent 1100 Series LC System and met the USP specifications for system suitability. Meeting the system suitability requirements is essential for laboratories to remain in compliance with the current Good Laboratory Practices regulations. Moreover, the ACQUITY QDa Detector in conjunction with UV detection enabled quick confirmation of peak identity by mass detection. Overall, the ACQUITY Arc System delivers reliable, robust, and reproducible results, which are key elements to enhance throughput and laboratory efficiency for routine testing in the QC laboratory.

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