ionKey/MS Ion Mobility: A New Approach to Authentication and Routine Screening of Ginsenoside Isomers in Functional Food Products

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M McCullagh, R Rao, J Chipperfield, and D Douce
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Application Notes
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Application Notes
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Ginseng is one of 11 species of slow-growing perennial plants with fleshy roots, that belong to the genus Panax of the family Araliaceae. The most abundant forms of ginseng Panax ginseng (Korean Ginseng), P. Japanoicus, and P. Quinquefolium (American Ginseng) grow in North America.

Ginseng is believed to offer different therapeutic benefits. For each species, it is believed that the ginsenoside and polysaccharides content are responsible for the biological activity of products produced from the roots and leaves of ginseng species.

While the growing global popularity of nutraceutical and functional food products continues to increase, for the European Union, current legislation aims to protect consumers from possible damaging side effects of over-the-counter herbal medicines and functional foods that are intended to deliver therapeutic benefits. EU Directive 2004/24/EC, came into full effect on 30 April 2011.

In this application note, we investigate the use of ion mobility MS and UPLC separations in combination with microflow chromatography for the specific and unambiguous identification of ginsenosides.

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