Probing Site-Specific Interactions Between Epidermal Growth Factor Receptor and an Adnectin Using HDX-ETD MS Approach

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Jing Fang, Asish Chakraborty, Ying Qing Yu, Hui Wei, Jingjie Mo, Daniel Cohen, Dianlin Xie, Zheng Lin, Paul E. Morin, Michael L. Doyle, Adrienne A. Tymiak, Weibin Chen, and Guodong Chen
Waters Corporation and Bristol-Myers Squibb Company
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In this work, authors applied HDX-MS coupled with ETD to probe the binding contacts at the amino acid residue levels in the EGFR/adnectin complex.

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