Suicide Inhibition of Oncogenic K-Ras G12C Proceeds via Shift to the Inactive Conformation

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Rane A. Harrison, Sang Min Lim, John C. Hunter, Kenneth D. Westover, Nathanael S. Gray, and John R. Engen
Northeastern University, Harvard Medical School, Dana-Farber Cancer Institute, and The University of Texas Southwestern Medical Center
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This study uses HDX MS to understand how covalent binding to K-Ras G12C by the GDP-analogue SML-8-73-1 altered the protein conformation.

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hdx_protein_conformational_perturbations_by_samll_molecule_hos_2015_secured PDF 144.18kB