Conformational Dynamics of the Src-family Kinase Hck upon HIV-1 Nef and Small Molecule Inhibitor Binding

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Jamie A. Moroco, Thomas E. Wales, Lori A. Emert-Sedlak, Thomas E. Smithgall, and John R. Engen
Northeastern University and University of Pittsburgh School of Medicine
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Authors study the conformational changes in the Src-family kinase Hck upon activation by HIV Nef and inhibition by small molecule binding.

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hdx_conformational_dynamics_engen_hos_2015_secured PDF 514.58kB