Why are LC Vials Showing Ghost Peaks with The New Generation of Mass Spectrometers?

Library Number:
LITR134841567
Part Number:
720005337EN
Author(s):
Claude R. Mallet, Brian P. Murphy
Source:
Waters
Content Type:
Literature
Content Subtype:
White Papers

In this application, leachable experiments were conducted with minimum manual labor. The Open Architecture UPLC System with 2D-LC Technology with infusion and at-column dilution configurations enabled 500:1 enrichment analysis by using large-volume injection (aqueous and organic). These two configurations eliminated the time-consuming evaporation-todryness and reconstitution steps. Overall, the results indicated a wide range of leachable entities in septum and vials; therefore, trace level analysis (low ppt range) now has to deal with these significant contributions.


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