Generation of Multiple Images from a Single Tissue Section with Dual Polarity Desorption Electrospray Ionization Mass Spectrometry

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Emmanuelle Claude, Emrys Jones
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Here we demonstrate that by optimizing DESI imaging conditions, a wealth of molecular information can be accessed from a single tissue section. Multiple images containing unique information can be collected from a tissue sample without the need for the analysis of a number of serial sections.

The advantages of DESI imaging include:

  • Optimization of DESI conditions allows multiple imaging experiments to be performed on the same tissue sample without altering the architecture or composition of the tissue
  • Both positive and negative ion mode DESI imaging data can be collected from a single tissue section
  • Using optimized DESI conditions enables subsequent analysis of tissue sections by other visualization techniques (i.e. H&E staining)

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