Due to cross reaction of the immunosorbent with interfering matrix, chloramphenicol can often be misdetected in milk resulting in the unnecessary destruction of the product. Mass detection offers increased selectivity, which helps differentiate between chloramphenicol and contaminating matrix. Furthermore, mass detection coupled with liquid chromatography (LC) eliminates the need for time-consuming derivatization typically required for screening of chloramphenicol by gas chromatography. In order to offer laboratories the opportunity to capture these benefits, recent advances in technology have focused on improving instrument usability and robustness. The ACQUITY QDa Detector can easily be integrated into LC workflows, with the ease of use that does not require specialist mass spectrometry knowledge.