Comparison of Fully and Superficially Porous Particle Columns for the Analysis of Basic Compounds

Library Number:
APNT10093529
Part Number:
720002825en
Author(s):
Kenneth J. Fountain, Jane Xu, Zhe Yin, Pamela C. Iraneta, Diane M. Diehl
Content Type:
Application Notes
Content Subtype:
Application Notes
Compounds:
uracil, pindolol, quinine, labetalol, prednisone, diltiazem, amitriptyline
Column:
10093534 XBridge C18 4.6 x 75 mm 10093535 SunFire C18 4.6 75 mm
Related Products:
 
 
Since the introduction of high performance liquid chromatography (HPLC) nearly 40 years ago, many developments have been made to column stationary phases to achieve faster, more efficient separations.  There are several ways of engineering a column in order to achieve these goals, including: increasing packed bed homogeneity, decreasing intra particle volume, narrowing particle size distribution, and decreasing the diffusion distance, which can be achieved, in part, by using smaller particles.  It can also be achieved by using superficially porous particles, which have a solid silica core and porous outer shell [1]. 

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