Comparison of Fully and Superficially Porous Particle Columns for the Analysis of Basic Compounds

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Kenneth J. Fountain, Jane Xu, Zhe Yin, Pamela C. Iraneta, Diane M. Diehl
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Application Notes
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uracil, pindolol, quinine, labetalol, prednisone, diltiazem, amitriptyline
10093534 XBridge C18 4.6 x 75 mm 10093535 SunFire C18 4.6 75 mm
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Since the introduction of high performance liquid chromatography (HPLC) nearly 40 years ago, many developments have been made to column stationary phases to achieve faster, more efficient separations.  There are several ways of engineering a column in order to achieve these goals, including: increasing packed bed homogeneity, decreasing intra particle volume, narrowing particle size distribution, and decreasing the diffusion distance, which can be achieved, in part, by using smaller particles.  It can also be achieved by using superficially porous particles, which have a solid silica core and porous outer shell [1]. 

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