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Supercritical CO2 Based Technologies (SFx)
ACQUITY Advanced Polymer Chromatography System
Supercritical Fluid Chromatography
Utilization of the ACQUITY PREMIER System and Column for Improved Oligonucleotide Bioanalytical Chromatographic Performance
Library Number:
APNT135080196
Part Number:
720007119EN
Author(s):
Kathryn Brennan, Mary Trudeau, Paul D. Rainville
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
ACQUITY UPLC System
Abstract / Summary
LC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robust analytical methods for their accurate quantification. This work highlights the increased chromatographic performance for oligodeoxythymidines (ODTs) and the oligonucleotide antisense therapy, GEM91, using the ACQUITY PREMIER chromatographic system.
Downloadable File(s)
| Title | Format | File Size |
|---|---|---|
| Download PDF | 697.79kB |