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Utilization of the ACQUITY PREMIER System and Column for Improved Oligonucleotide Bioanalytical Chromatographic Performance

Library Number:
APNT135080196
Part Number:
720007119EN
Author(s):
Kathryn Brennan, Mary Trudeau, Paul D. Rainville
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Technical Notes
Related Products:
ACQUITY UPLC and ACQUITY PREMIER Columns
 
MassLynx MS Software
 
ACQUITY UPLC System
 
Oligonucleotide Analysis
 
Xevo TQ-XS Triple Quadrupole Mass Spectrometry
 
ACQUITY PREMIER Solution
 
Otto SPEcialist Positive Pressure Manifold
 
PREMIER Columns
 
ACQUITY PREMIER System
Abstract / Summary

LC-MS/MS bioanalytical quantification of oligonucleotide therapeutics requires sensitive and robust analytical methods for their accurate quantification. This work highlights the increased chromatographic performance for oligodeoxythymidines (ODTs) and the oligonucleotide antisense therapy, GEM91, using the ACQUITY PREMIER chromatographic system.


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