Separation and Detection of an Azido Impurity in Sartan Drug Substances Using the XSelect CSH Phenyl-Hexyl Column by UHPLC-UV-MS

Library Number:
APNT135088337
Part Number:
720007369EN
Author(s):
Kenneth D. Berthelette, Jennifer M. Nguyen, Mary Trudeau, Jonathan E. Turner
Source:
Waters
Content Type:
Application Notes
Content Subtype:
Application Notes
Related Products:
Pharmaceutical
 
 
 
 
 
 

This application note demonstrates UHPLC method with dual UV-MS detection for the quick and accurate, 3-minute analysis of this azido impurity, 5-[4’-(azidomethyl)-[1,1’-biphenyl]-2-yl)-1H-tetrazole, and the sartan APIs irbesartan, lorsartan, and valsartan using an XSelect CSH Phenyl-Hexyl Column.


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